Genetic Risk Factors
The genetics for Atopic Dermatitis aren't completely understood. Studies show that several genes could be involved in the conditions development. Although the strongest connection is with the FLG gene. This gene has been mutated in 30 percent of people who have atopic dermatitis. FLG gene provides instructions for making a protein called profilaggrin, which is cut (cleaved) to produce multiple copies of the filaggrin protein. Filaggrin is involved in creating the structure of the outermost layer of skin, creating a strong barrier to keep in water and keep out foreign substances, including toxins, bacteria, and substances that can cause allergic reactions, such as pollen and dust.
Genetics Home Reference (2017). Atopic Dermatitis. ghr.nlm.nih.gov/condition/atopic-dermatitis
Genetics Home Reference (2017). Atopic Dermatitis. ghr.nlm.nih.gov/condition/atopic-dermatitis