Animal Studies of Eczema in General:
Different species of animals are used for the research of Eczema. These animals include: mice, cats, dogs, and horses. These animals can develop atopic eczema type symptoms. These large animals sometimes don't fit the criteria for the research, so researchers use mice instead. They can use different types of mice such as: genetically engineered mice (Knock-out, transgenic), and humanized mice models. Mice have skin very similar to humans and that is why they are used most commonly in animal research for eczema.
-Johana C.
Gutermutha, J. (2004).Mouse Models of Atopic Eczema Critically Evaluated. Retrieved from https://mediatum.ub.tum.de/doc/1218925/1218925.pdf.
Different species of animals are used for the research of Eczema. These animals include: mice, cats, dogs, and horses. These animals can develop atopic eczema type symptoms. These large animals sometimes don't fit the criteria for the research, so researchers use mice instead. They can use different types of mice such as: genetically engineered mice (Knock-out, transgenic), and humanized mice models. Mice have skin very similar to humans and that is why they are used most commonly in animal research for eczema.
-Johana C.
Gutermutha, J. (2004).Mouse Models of Atopic Eczema Critically Evaluated. Retrieved from https://mediatum.ub.tum.de/doc/1218925/1218925.pdf.
Researching Atopic Dermatitis on Mice -Kiera
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Researchers use mice as an animal model because mice have similar skin to humans. Like humans, mice skin lesions is
influenced by genetic- as well as environmental factors. A research done with mice have identified the serotonin receptor HTR7 as a key mediator of eczema and other forms of chronic itch. UC Berkeley neuroscientist Diana Bautista, Ph.D., and Buck Associate Professor Rachel Brem, Ph.D., a geneticist both came up with this conclusion by researching on mice. New findings in mice concluded itching and scratching can be side effects of taking antidepressants. Therefore, taking antidepressants for Eczema should not be your first choice. Buck Institute for Age Research(2015, June 11) Serotonin Receptor is Involved in Eczema and other Itch Conditions. ' https://www.sciencedaily.com/releases/2015/06/150611122953.htm |
"This mouse was involved in the study which identified serotonin receptor HTR7 as a key mediator of chronic itch."
Credit: Courtesy of Diana Bautista, UC Berkeley https://www.sciencedaily.com/releases/2015/06/150611122953.htm |
Atopic Dermatitis on Dogs
Demerra McDowell
In dogs with Eczema studies examining number of mast cells and the histamine release between normal and dogs with Eczema showed no differences, or even a lower mast cell density. Studies evaluating serum histamine concentrations revealed that levels are similar or lower in dogs with AD compared to healthy controls.
picture from http://www.dogbreedinfo.com/care/hotspotsdog.htm
Demerra McDowell
In dogs with Eczema studies examining number of mast cells and the histamine release between normal and dogs with Eczema showed no differences, or even a lower mast cell density. Studies evaluating serum histamine concentrations revealed that levels are similar or lower in dogs with AD compared to healthy controls.
picture from http://www.dogbreedinfo.com/care/hotspotsdog.htm